South Carolina 501(c)(3) Lookup

South Carolina is home to more than 29,000 nonprofit organizations — many of which have religious missions. Advanced Technology International, Prisma Health-Upstate, and Prisma Health-Midlands are among the state’s largest 501c3 nonprofits.

Interested in finding which organizations in South Carolina are 501c3s? Use our nonprofit lookup tool to search nonprofit organizations and see if the charity you are looking for has 501c3 status.

501c3 organizations are nonprofit corporations that meet specific IRS criteria. Donations to a 501c3 are usually tax-exempt. Use our 501c3 lookup table to find out whether or not an organization has 501c3 status.

501(c)(3) Lookup for South Carolina

South Carolina Nonprofits

Many nonprofits in South Carolina focus on issues like cancer treatment, disease research, and gender equality. Below, you’ll find three nonprofits whose work in these fields earned them positive recognition within the state.

Neuroendocrine Cancer Awareness Network (NCAN)

This nonprofit works to raise awareness about and, ultimately, end neuroendocrine cancer — a form of cancer that can cause radical changes in the body’s hormones through overproduction or underproduction. Since 2003, NCAN has funded research into the ailment and supported those diagnosed with it along with their caregivers. As one of the leading forces combating neuroendocrine cancer, NCAN produces conferences and exhibits at medical trade shows to spread the latest news about this disease and current treatment methods. 


Tracheobronchomalacia (TBM) is a condition that weakens an individual’s trachea and bronchi, leading to difficulty breathing and the potential for collapsed airways. CureTBM seeks to end this often-misdiagnosed breathing condition by funding research into TBM treatments and a potential cure. It also provides emotional and financial support to those affected by this condition. While TBM went underdiagnosed and untreated by the majority of doctors for years, CureTBM hopes its efforts will mean this condition no longer remains incurable.

Together Women Rise

Originally founded in South Carolina in 2003, this nonprofit has since blossomed into an international organization. It fights for gender equality across the planet by advocating for women and sponsoring organizations that seek to help empower women — both domestically and in countries around the world. Each year, Together Women Rise awards grants to organizations that support its cause and provide tangible benefits to women struggling in low-income environments who seek to better their lives. This nonprofit also educates the public on matters of gender inequality and connects women with others who can assist them in their current circumstances and, ultimately, help them to better themselves.